diff --git a/CMakeLists.txt b/CMakeLists.txt
index 5e47edcca..545acfee5 100644
--- a/CMakeLists.txt
+++ b/CMakeLists.txt
@@ -154,6 +154,10 @@ if(ARCH_ID STREQUAL "powerpc")
   set(PPC     1)
 endif()
 
+if(ARCH_ID STREQUAL "s390x")
+  set(S390X 1)
+endif()
+
 if(WIN32 OR ARM OR PPC64LE OR PPC64 OR PPC)
   set(OPT_FLAGS_RELEASE "-O2")
 else()
@@ -626,12 +630,14 @@ else()
     message(STATUS "AES support explicitly disabled")
     set(CMAKE_C_FLAGS "${CMAKE_C_FLAGS} -DNO_AES")
     set(CMAKE_CXX_FLAGS "${CMAKE_CXX_FLAGS} -DNO_AES")
-  elseif(NOT ARM AND NOT PPC64LE AND NOT PPC64 AND NOT PPC)
+  elseif(NOT ARM AND NOT PPC64LE AND NOT PPC64 AND NOT PPC AND NOT S390X)
     message(STATUS "AES support enabled")
     set(CMAKE_C_FLAGS "${CMAKE_C_FLAGS} -maes")
     set(CMAKE_CXX_FLAGS "${CMAKE_CXX_FLAGS} -maes")
   elseif(PPC64LE OR PPC64 OR PPC)
     message(STATUS "AES support not available on POWER")
+  elseif(S390X)
+    message(STATUS "AES support not available on s390x")
   elseif(ARM6)
     message(STATUS "AES support not available on ARMv6")
   elseif(ARM7)